Floating tablet of levofloxacin hemihydrate was prepared by direct compression technique. Levofloxacin hemihydrate was chosen as model drug because it is effective for the eradication of H. pylori and it has site-specific absorption in stomach and plasma half life of 5-6 hrs as well. All these criteria make levofloxacin hemihydrate suitable candidate for floating Tablet. Kollidon® SR was used as directly compressible vehicle and floating carrier. A 32 randomized full factorial design was applied to optimize variables. Amount of hydroxyl propyl methyl cellulose HPMC K4M (X1) and sodium starch glycolate SSG (X2) were selected as independent variables. The Cumulative percentage drug release was selected as dependent variable. HPMC K4M was used as a hydrophilic polymer, to control the release of highly water soluble levofloxacin hemihydrates and SSG was added not for disintegrating the tablets, but lower concentration of superdisintegrant in the matrix tablet increases the surface erosion of the tablet thereby increases the drug release rate. The tablets were evaluated for in-vitro buoyancy and dissolution studies. The tablets were evaluated for physical characteristic viz. hardness, floating capacity, thickness, friability and weight variation. Further, tablets were evaluated for in-vitro release characteristic for 10 hrs. To confirm the exact mechanism of drug release from different formulation, the data was fitted to korsmeyer peppas equation and value of correlation coefficient in korsmeyer – peppas model was nearer to 1 than any other model which indicates best fitting model for all the batches of factorial design.
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